It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. How to bill for following plaquenil retina Chloroquine sigma autophagy CPPD can cause bouts of severe pain and swelling in one or more joints, which can limit activity for days or weeks. It also can cause a more lasting arthritis that mimics osteoarthritis or rheumatoid condition most often involves the knees, but can affect wrists, shoulders, ankles, elbows, hands or other joints. Thyroid disease can lead to inflammatory joint disease, including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Learn about the connection between these conditions, including I have a mild form of rheumatoid arthritis serum positive, treated with Plaquinel 400mg daily and Naproxan 1000mg daily for the past 6 years. I have had no problems with the arthritis in all that time and still don't. My question is about the Plaquinel. This summer I started having skin discoloration on the top of both of my feet. The color of my skin turned a deep blackish blue color. Could. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. It may be as long as 12 weeks before you notice the benefits. Plaquenil and juvenile arthritis blue fingers Plaquenil User Reviews for Rheumatoid Arthritis at, Thyroid Disease and Arthritis How They're Connected Plaquenil and sulfasalazineWhat effect does plaquenil have on the bodyIs hydroxychloroquine a time release pill Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis or juvenile idiopathic arthritis and other autoimmune diseases. It is not clear why hydroxychloroquine is effective at treating autoimmune diseases. Hydroxychloroquine Plaquenil. Skin Discoloration and Plaquenil • Johns Hopkins Arthritis.. Hydroxychloroquine Side-effects, uses, time to work. Hi guys, I was diagnosed with RA in April 08 and I'm 29 years old. My doctor was only able to find it after I requested a MRI of my hands. He believed it was in the very early stages and not extremely bad so prescribed Plaquenil/Hydroxychloroquine since it is the RA drug with the least side effects he said. Plaquenil is a DMARD which has been prescribed for years to treat rheumatoid arthritis, lupus, juvenile rheumatoid arthritis, and other autoimmune diseases. When the first biologic DMARD received FDA-approval in 1998, and as other biologics followed in subsequent years, it appeared as though Plaquenil would become less prescribed. Raynaud’s disease, which causes fingers and/or toes turn white or blue when cold. Sjogren’s syndrome, which causes dry eyes, mouth and vagina. Ankylosing Spondylitis Fibromyalgia Gout Juvenile Arthritis Lupus Osteoarthritis Psoriatic Arthritis Rheumatoid Arthritis Other.