Pharmacology of chloroquine

Discussion in 'Plaquenil Generic' started by ZYV, 08-Mar-2020.

  1. tranceloud New Member

    Pharmacology of chloroquine


    Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. This medication is used to kill the malaria parasites living inside red blood cells.

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    Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Chloroquine has two basic groups corresponding to the quinoline-ring nitrogen and the diethylamino side-chain nitrogen with ionization constants of 8.1 and 10.2, respectively 33–36. At a physiologic pH of 7.4, 18 % of chloroquine is monoprotonated but still soluble in lipid and able to traverse cell membranes. Pharmacology Indication Chloroquine is indicated to treat infections of P. vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. 18 It is also used to treat extraintestinal amebiasis. 18

    Both drugs may be needed for a complete cure and to prevent the return of infection (relapse). In some cases, you may need to take a different medication (such as primaquine) to kill the malaria parasites living in other body tissues.

    Pharmacology of chloroquine

    Chloroquine Information for Providers AIDSinfo, Pharmacology of Chloroquine and Hydroxychloroquine Ento Key

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  3. Apr 02, 2019 CLINICAL PHARMACOLOGY. Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract, and only a small proportion of the administered dose is found in the stools. Approximately 55% of the drug in the plasma is bound to nondiffusible plasma constituents.

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    Oct 01, 2018 Chloroquine - Clinical Pharmacology Chloroquine is rapidly and almost completely absorbed from the gastrointestinal tract, and only a small proportion of the administered dose is found in the stools. Approximately 55% of the drug inthe plasma is bound to nondiffusible plasma constituents. Chloroquine, introduced into medicine in the 1940s, is a member of an important series of chemically related antimalarial agents, the quinoline derivatives. Chloroquine is administered orally as chloroquine phosphate. It also can be given by intramuscular injection as chloroquine hydrochloride. Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities.

     
  4. darikoru Moderator

    Hydroxychloroquine is a one of a number of drugs which have been used for many years in the treatment of malaria. Plaquenil oral Reviews and User Ratings Effectiveness, Ease of Use. Hydroxychloroquine Plaquenil Taking Plaquenil for Rheumatoid Arthritis
     
  5. RomanPetrov Guest

    Hydroxychloroquine Dosage Guide with Precautions - Initial dose 400 mg 310 mg base orally 1 to 2 times a day; this dose may be continued for several weeks or months, depending on patient response. Maintenance dose 200 to 400 mg 155 to 310 mg base orally daily. Comments -Each dose should be taken with a meal or a glass of milk.

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