Chloroquine dna intercalation

Discussion in 'Northwest Pharmacy Canada' started by Serik, 13-Mar-2020.

  1. VICTOR2589KZ Moderator

    Chloroquine dna intercalation


    Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties.

    Faf plaquenil screening Hydroxychloroquine and tanning Hydroxychloroquine and chloroquine retinopathy screening for drug toxicity

    In biochemistry, intercalation is the insertion of molecules between the bases of DNA. This process is used as a method for analyzing DNA and it is also the basis of certain kinds of poisoning. Clathrates are chemical substances consisting of a lattice that traps or contains molecules. Usually, clathrate compounds are polymeric and completely envelop the guest molecule. Chloroquine is reported in the literature to be a weak genotoxic agent that may elicit both gene mutations and chromosomal/DNA breaks. Mechanisms may involve DNA intercalation or induction of oxidative stress. Both positive and negative results have been reported with in vitro reverse gene mutation assays and with in vivo animal studies. The same effect was observed under local DNA unwinding upon chloroquine intercalation around the sites of the attachment of DNA to proteins. The topological interaction protein intercalation into the double helix between DNA loop ends and nucleoid proteins is discussed.

    In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms).

    Chloroquine dna intercalation

    Binding of chloroquine to DNA - ScienceDirect, Chloroquine Phosphate chloroquine phosphate dose.

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  6. Vitro Gene Transfection. Chloroquine CQ is an analogue of quinoline that has a chloro group at the 7-position and an aliphatic amino side chain at the 4-position Chart 1. Because of the aromatic ring-structure,CQ can intercalate DNA22,23 and facilitate the unpackaging of DNA from polyplexes.8 CQ is also * To whom correspondence should be addressed.

    • Structure Function Correlation of Chloroquine and Analogues as..
    • Protein intercalation in DNA as one of main modes of fixation..
    • The DNA Intercalation Assay - Inspiralis.

    The response of ssDNA sensor was caused by interaction of phosphates groups of DNA with chloroquine cations. However, the response of dsDNA sensor was caused not only by interaction of phosphates groups of DNA with chloroquine cations but also by intercalation of chloroquine cations into dsDNA double strand helix, which leads the response greater. Synthesis, characterization, and biological activity of cis-diammineplatinumII complexes of the DNA intercalators 9-aminoacridine and chloroquine Wesley I. Sundquist Daniel P. Bancroft Chloroquine is a member of quinolone family and is a weak intercalating agent. Chloroquine is used for treating amebiasis, rheumatoid arthritis, discoid and systemic lupus erythematosus. Application DNA intercalator. Also used to increase transfection efficiency. Chloroquine diphosphate salt has been used • in in vitro antiplasmodial assays

     
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  8. Eclipse User

    RA and Hydroxychloroquine How Effective is it for. According to the American College of Rheumatology, hydroxychloroquine Plaquenil, is a “disease-modifying anti-rheumatic drug DMARD,” meaning that it helps reduce the pain and swelling that come with arthritis. It can also reduce the incidence of joint damage, thus lessening the risk of developing a long-term disability from complications of RA.

    Hydroxychloroquine - Wikipedia
     
  9. Jojagif Moderator

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