Plaquenil and diabetic retinopathy

Discussion in 'North West Pharmacy Canada' started by tutonhamon_, 22-Feb-2020.

  1. etraff.com XenForo Moderator

    Plaquenil and diabetic retinopathy


    She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation.

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    Diabetic retinopathy develops in people with type 1 or type 2 diabetes. It takes years to develop. Two kinds of diabetic retinopathy have the potential to diminish vision In nonproliferative retinopathy, blood vessels in the retina deteriorate. Deteriorating blood vessels can become blocked or deformed. This is the first study that focuses on assessing retinopathy risk by tracking hydroxychloroquine blood levels. Despite the benefits of treatment, which may also include anti-thrombotic and anti-diabetic effects and complete renal remission when given in combination with mycophenolate mofetil, the risks have been well documented. Johnson and Vine examined nine patients taking a cumulative dose of hydroxychloroquine of greater than 1,000 g and noted that eight patients taking 400 mg/d had no evidence of retinopathy, whereas one patient taking more than 600 mg/d had retinopathy. 5 Bernstein concurred with this study, but noted that patients with chronic renal.

    Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use.

    Plaquenil and diabetic retinopathy

    Hydroxychloroquine toxicity - EyeWiki, Retinopathy Risk in Lupus Increases With Longer.

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  7. The symptoms of Plaquenil retinopathy are usually quite subtle at the onset and may include distortion, dimming, or blurring of vision, difficulty reading, sensitivity to light, flickering lights, or colored haloes around lights. More severe damage may cause blind spots in the central portion of the visual field and loss of visual acuity.

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    Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy Retinal toxicity from chloroquine CQ and its analogue, hydroxychloroquine HCQ, has been recognized for many years. Chloroquine toxicity remains a problem in many parts of the world, but is seen less frequently in the United States where the drug largely has been replaced by HCQ. Hydroxychloroquine and Chloroquine Retinopathy is the first single-source book on the subject and is essential for the practicing ophthalmologists, rheumatologists, dermatologists, and internists who prescribe these drugs. It covers clinical topics such as signs and symptoms of toxicity, toxicity screening, ancillary testing, to whom and why the drugs are prescribed and dosing considerations. Hydroxychloroquine oral tablet is available as a brand-name drug and a generic drug. Brand name Plaquenil. Hydroxychloroquine comes only as a tablet you take by mouth. Hydroxychloroquine is used to treat malaria, lupus erythematosus, and rheumatoid arthritis.

     
  8. Mir_Mramora XenForo Moderator

    In some cases, they may not be available in every strength or form as the brand-name drug. Methotrexate sodium oral and omeprazole oral Drug Interactions - RxList Prednisone and Plaquenil drug interactions - eHealthMe Methotrexate and Proton Pump Inhibitors
     
  9. Alexandr83 New Member

    Pharmacokinetics, Pharmacodynamics, and Allometric Scaling. For example, the clearance of CQ from whole blood and plasma is approximately 0.1 to 0.25 liter/h/kg of body weight and 0.5 to 0.9 liter/h/kg, respectively, in healthy volunteers, and the t 1/2 of CQ is 150 to 290 h 17–19, 32, 35, 47, 59.

    Protein Binding and Blood To Plasma Ratio Cell.