I did stop it for 2 weeks early in the treatment due to having to take a coupld other drugs that seemed to give me side effects. I just quit the plaquenil to give my liver a rest at that time. Plaquenil isn a antiparasitic drug with anti-inflammatory affect. Plaquenil skin side effects pictures Drugs administered with chloroquine Plaquenil for vasculities rash Plaquenil, what to expect for the first time taking it. Skyllark • • 6 Replies. My wife will be taking Plaquenil for the first time, is there any things she should expect in taking it in starting to take the medication. Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals. The first dose is taken 1 to 2 weeks before traveling to an area where malaria is common, and then doses are continued for 8 weeks after exposure. For treatment of acute attacks of malaria in adults, four tablets are usually taken right away, followed by two tablets 6 to 8 hours later and then two tablets on each of the next 2 days. The first dose of Plaquenil is usually taken one to two weeks before traveling to an area where malaria is prevalent. Doses are then continued for four weeks after exposure. Over the years on this site we have had quite a few people post that they didn't think that the plaquenil was working so they would stop taking it. I have done a lot of research on this drug and haven't run into anybody who has complained of the withdrawal effect. What to expect when taking plaquenil for the first time Plaquenil Oral Uses, Side Effects, Interactions., Hydroxychloroquine MedlinePlus Drug Information Chloroquine and primaquine malaria Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine Plaquenil. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus Center. I recently decided to stop taking Plaquenil because I was having constant chest pains even more so than I usually have due to Lupus. Since I have not taken it my chest feels so much better which is odd because chest pain is not listed as a side effect. Also I noticed that the Plaquenil I think was making me feel different but not in a good way. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. You will likely have to take additional medications to keep your rheumatoid arthritis in control. Depending on what you're being treated for, it can take up to 6 months for the full benefits of Plaquenil hydroxychloroquine. Many people have nausea, stomach cramps, and diarrhea when they first start taking Plaquenil hydroxychloroquine.