Physicochemical properties of chloroquine hydrochloride

Discussion in 'Chloroquine' started by wolf-wolf, 21-Feb-2020.

  1. Physicochemical properties of chloroquine hydrochloride


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

    Hydroxychloroquine gh 200 mg Administration with chloroquine

    The influence of grinding, milling and sieving on the powders was also investigated. Methods For phenylephrine hydrochloride two different crystal types were prepared through recrystallisation from different solvents and the physicochemical properties these crystal modifications were determined by means of XRPD and IR. The physicochemical properties of halofantrine hydrochloride HF HCl--a phenanthrene methanol antimalarial, were determined practically in this study since such experimental values are still unknown. Chloroquine is in trials as an antiretroviral for HIV-1/AIDS and is being considered in pre-clinical models as a potential agent against chikungunya fever. Other. The radiosensitizing and chemosensitizing properties of chloroquine are beginning to be exploited in anticancer strategies in humans.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Physicochemical properties of chloroquine hydrochloride

    Chloroquine Oral Uses, Side Effects, Interactions, Pictures., PDF Determination of the physicochemical properties of.

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  4. The hydrochloride salt of chloroquine, a synthetic quinoline with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum.

    • Chloroquine hydrochloride Semantic Scholar.
    • Chloroquine - Wikipedia.
    • Chloroquine hydrochloride - DrugBank.

    Physicochemical and biological activities J. F. Adediji*, E. T. Olayinka, M. A. Adebayo and O. Babatunde Department of Chemical Sciences, Ajayi Crowther University, P. M. B 1066, Oyo, Nigeria. Accepted 21 July, 2009 Complexation behaviour of mixed complexes of mefloquine hydrochloride and chloroquine phosphate The result can also be predicted from an analysis of the physicochemical properties of CQ and HCQ. To give limited protective effect similar to 300 mg CQ base weekly against CQ-resistant P. falciparum would demand daily doses of HCQ above the recommended safe level. These observations contraindicate the use of HCQ in prophylaxis or treatment of CQ-resistant falciparum malaria. Physicochemical characteristics Molecular weight— Chloroquine 319.88 Chloroquine hydrochloride 392.80 Chloroquine phosphate 515.87 Mechanism of action/Effect Antiprotozoal—Malaria Unknown, but may be based on ability of chloroquine to bind to and alter the properties of DNA.

     
  5. atominfo User

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine Dosage Guide with Precautions - Chloroquine mechanism of drug action and resistance in. Plasmodium falciparum pre-erythrocytic stage vaccine.
     
  6. devinspb Moderator

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Treating Lupus with Anti-Malarial Drugs Johns Hopkins. Hair Loss - General - Sjogren's Syndrome Support Ask the Expert Plaquenil and Sjögren’s
     
  7. dorinbo User

    Hydroxychloroquine-Induced Retinal Toxicity - American. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.

    Treatment of hydroxychloroquine overdose - ScienceDirect
     
  8. pilot_mick XenForo Moderator

    Quantitative assessment of outer retinal layers and ellipsoid. To date, several investigators have used SD-OCT in eyes with HCQ toxicity and qualitatively evaluated thinning of the outer retinal layers or attenuation of the ellipsoid zone EZ, while others have quantitatively analysed outer retinal thickness on SD-OCT topographic map.7–10 This study aims to characterise HCQ toxicity using a newly.

    How to Succeed in Plaquenil Screenings