In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Plaquenil and myasthenia gravis Hydroxychloroquine how long does it stay in body What happens when you take plaquenil with out having lupus Hydroxychloroquine-Induced Hyperpigmentation. From the Departments of *Rheumatology and †Dermatology, Walter Reed National Military Medical Center; and ‡Uniformed Services University of the Health Sciences, Bethesda, MD. No financial support was received for this study. The authors declare no conflict of interest. Skin figure 1A,B. There was no pigmentation at other body sites. Biopsy from the plaque showed necrobiotic collagen with intradermal mucin and perivascular lymphohistiocytic infiltrate accom-panied by brown coarse pigment in the dermis figure 1C,D. The pigment was negative on Perl’s stain figure 1E. This was a unique pattern of Our data support the hypothesis that hydroxychloroquine-induced pigmentation is secondary to ecchymosis or bruising. OBJECTIVE To describe the clinical features and outcome of hydroxychloroquine HCQ-induced pigmentation in patients with systemic lupus erythematosus SLE. Download PDF Many systemic medications may cause retinal toxicity. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Hydroxychloroquine-induced pigmentation Hydroxychloroquine-induced hyperpigmentation in systemic., Hydroxychloroquine induced cutaneous pigmentation a unique pattern Plaquenil and psychosisPlaquenil knee side effectsHydroxychloroquine use during pregnancyChloroquine injection dosage for adults J Eur Acad Dermatol Venereol. 2006 Apr;204487-8. Hydroxychloroquine-induced pigmentation in two patients with systemic lupus erythematosus. Hydroxychloroquine-induced pigmentation in two patients with.. Hydroxychloroquine-induced pigmentation in patients with.. Skin Pigmentation with Hydroxychloroquine Plaquenil.. Conclusions HCQ-induced pigmentation is considered uncommon adverse effect of HCQ, with a prevalence rate of 49.2% indicated in this study. Furthermore, history of bruising, sun exposure, and the presence of mucous membrane pigmentation are possible predisposing factors. Hydroxychloroquine pigmentation can occur within 1 year after starting therapy 4, 12, 13, 17. The skin discoloration has no systemic adverse sequelae. The skin discoloration has no systemic. Drug-induced pigmentation is not generally associated with any systemic toxicity and thus has an excellent prognosis. With some exceptions, pigmentation is usually reversible and slowly fades with discontinuation of the drug.