Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Does plaquenil help fibromyalgia Chloroquine pregnancy Does plaquenil help neuropathy Fundus Autofluorescence FAF. Plaquenil Hydrochloroquine or Aralen Chloroquine • Annual screening after 5 years of use **Interesting, The Royal College of Ophthalmologists in Great Britain does NOT recommend routine screening for toxicity with antimalarial drug use. Dec 04, 2014 This baseline evaluation entails a dilated fundus examination, 10-2 white pattern visual field test subjective, and at least one of the following objective tests Spectral-domain optical coherence tomography SD-OCT, fundus autofluorescence FAF, or multifocal electroretinogram mfERG. Fundus autofluorescence FAF is a non-invasive imaging technique that detects fluorophores, naturally occurring molecules that absorb and emit light of specified wavelengths 1. To produce autofluorescence, a fluorophore absorbs a photon of the excitation wavelength, which elevates an electron to an excited, high energy state. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Fundus autofluorescence plaquenil Hydroxychloroquine Plaquenil Toxicity and Recommendations., Hydroxychloroquine retinopathy A review of imaging Hydroxychloroquine teratogenicFundus in chloroquinePlaquenil usage and autismHydroxychloroquine test for eyesIs hydroxychloroquine a dmard At right, FAF image shows large soft drusen associated with increased fundus autofluorescence in a patchy FAF pattern. There are also more defined areas of hyper-AF corresponding to mixed drusen in a focal increased pattern superior and inferior to the fovea. A Clinical Guide to Fundus Autofluorescence. Clinical applications of fundus autofluorescence in.. Plaquenil Toxicity - Mild - Partial Bull's Eye Maculopathy.. The maximum dose of Plaquenil is 6.5 mg/kg of ideal body weight per day, regardless of whether a person is overweight, underweight, or normal weight. One kilogram kg equals 2.2 pounds. Women with lupus who are OVER their ideal body weight should go by these dosing rules 5’ 7” or higher - up to 400 mg Plaquenil daily Fundus autofluorescence, or FAF is an imaging technique utilized to aid in the documentation and monitorization of retina health and function. The retina is the neurosensory layer of the eye that transmits the optical images we see into the electrical images our brain understands. Fundus autofluorescence patterns in various stages of hydroxychloroquine retinopathy. Classic bull’s-eye maculopathy appearance A. As the RPE atrophies, the FAF intensity in the pericentral macula changes to a mottled, or speckled appearance B, and eventually coalesces into dark areas of absence of FAF signal once the cells have died C.