Chloroquine for research

Discussion in 'Canadian Pharmacy' started by Gudvin, 23-Feb-2020.

  1. Slog New Member

    Chloroquine for research


    Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

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    Recently, an altered chloroquine-transporter protein CG2 of the parasite has been related to chloroquine resistance, but other mechanisms of resistance also appear to be involved. Research on the mechanism of chloroquine and how the parasite has acquired chloroquine resistance is still ongoing, as other mechanisms of resistance are likely. Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine works best when you take it on a regular schedule. For example, if you are taking it once a week to prevent malaria, it is best to take it on the same day of each week. Make sure that you do not miss any doses. If you have any questions about this, check with your doctor.

    Chloroquine is also used to treat amebiasis (infection caused by amoebae). Chloroquine is used to treat and to prevent malaria.

    Chloroquine for research

    Effects of chloroquine on viral infections an old drug against today's., Chloroquine C18H26ClN3 - PubChem

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  5. Chloroquine data from Covid-19 trials. Data from the drug’s studies showed ‘certain curative effect’ with ‘fairly good efficacy’. According to Sun, patients treated with chloroquine demonstrated a better drop in fever, improvement of lung CT images, and required a shorter time to recover compared to parallel groups.

    • Coronavirus Covid-19 Chloroquine data; Japan to trial HIV drug.
    • Chloroquine Oral Route Proper Use - Mayo Clinic.
    • Remdesivir and chloroquine effectively. - Cell Research.

    TI is not great on Chloroquine, and if someone is dying of SARS-CoV-2 you don't care about side effects too much and push it up to the limit, but would be a real concern for broader prophylaxis use where you'd want to dose less if you could but might lose benefit in that case. Some background research on this In past research, chloroquine has shown in vitro activity against many different viruses, but no benefit in animal models. • Chloroquine has been proposed several times for the treatment of acute viral diseases in humans without success. • The outcomes of some current clinical trials of chloroquine in China have been announced, without. Chloroquine is an aminoquinoline used for the prevention and therapy of malaria. It is also effective in extraintestinal amebiasis and as an antiinflammatory agent for therapy of rheumatoid arthritis and lupus erythematosus. Chloroquine is not associated with serum enzyme elevations and is an extremely rare cause of clinically apparent acute liver injury.

     
  6. VitArt New Member

    People with flu can spread it to others up to about 6 feet away. Hydroxychloroquine oral and influenza virus vac. tri-split. Preventing the Spread of Flu in the Workplace CDC How to Survive Cold and Flu Season with Inflammatory Arthritis
     
  7. [email protected] XenForo Moderator

    Chloroquine diphosphate Supplier CAS 50-63-5 Tocris. Sasaki et al 2010 Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells. BMC Cancer 10 370 PMID 20630104. If you know of a relevant reference for Chloroquine diphosphate, please let us know.

    Chloroquine phosphate C18H32ClN3O8P2 - PubChem
     
  8. a.smelyansky XenForo Moderator

    Rheumatoid Arthritis Treatment Options Johns Hopkins. Hydroxychloroquine is an antimalarial drug which is relatively safe and well-tolerated agent for the treatment of rheumatoid arthritis. Chloroquine is another antimalarial agent that is also sometimes used.

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