Chloroquine induces degradation

Discussion in 'Canadian Pharmacy Drugs Online' started by JBourne, 25-Feb-2020.

  1. prudis Moderator

    Chloroquine induces degradation

    It accumulates inside the acidic parts of the cell, including endosomes and lysosomes. This accumulation leads to inhibition of lysosomal enzymes that require an acidic p H, and prevents fusion of endosomes and lysosomes. TLR7/8-Mediated Activation of Human NK Cells Results in Accessory Cell-Dependent IFN- Production.

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    Yao et al. revealed that during osteoclastogenesis, neither RANKL-induced TRAF3 degradation nor the effect of chloroquine on preventing TRAF3 degradation is influenced by knockout of TRAF6. Together, we cautiously concluded that there might not be a direct association between RANKL-induced TRAF3 degradation and RANKL–regulated signaling cascade. TY - JOUR. T1 - In vivo chloroquine-induced inhibition of insulin degradation in a diabetic patient with severe insulin resistance. AU - Blazar, Bruce R The effect of chloroquine, an inhibitor of certain lysosomal enzymes including cathepsin B EC, on the degradation of serum lipoproteins in

    Moreover, Chloroquine inhibits autophagy as it raises the lysosomal p H, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation [4]. Chloroquine is commonly used to study the role of endosomal acidification in cellular processes [2, 3], such as the signaling of intracellular TLRs.

    Chloroquine induces degradation

    Chloroquine in Cancer Therapy A Double-Edged Sword of., In vivo chloroquine-induced inhibition of insulin.

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  5. Chloroquine has been reported to give toxic reactions which may be ascribed to the photochemical degradation of the substance. The effects of light at wavelengths of 240–600 nm on solutions of chloroquine in isopropanol, and of light at wavelenghts of 320–600 nm on solutions of chloroquine in buffer solutions were investigated.

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    Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum. Geng Y, Kohli L, Klocke BJ, Roth KA. Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent. Neuro Oncol. The findings that chloroquine induces apoptosis and activates the p53 pathway raised the question of a causal link between the two phenomena. To address this question, we assessed the effects of p53 knockdown on the efficacy of apoptosis induced by chloroquine. The antimalarial drug chloroquine CQ disrupts autophagy by inhibiting the acidification of the lysosomes that fuse with the autophagosomes, thereby preventing the degradation of metabolic stress products and inducing apoptosis. Chloroquine-mediated inhibition of autophagy has been demonstrated in melanoma.

  6. and371 Well-Known Member

    The clinical features of drug-induced photosensitivity vary according to the photosensitising agent involved and the type of reaction it causes in the skin. Plaquenil and Sun Sensitivity - Reviews - Treato Will you have Photosensitivity reaction with Plaquenil. Photosensitivity Reaction With Certain Medications
  7. rushelp New Member

    Focus on Eyes Long-term Plaquenil intake can affect your vision Focus on Eyes Long-term Plaquenil intake can affect your vision. Taking high doses or long-term treatment of Plaquenil, an anti-malaria drug used to treat lupus, can lead to vision problems.

    Protecting your eyesight when taking Plaquenil Lupus.