Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Taking plaquenil and drinking alcohol Does plaquenil work for scleroderma Plaquenil ocular report Benefits of using plaquenil Stevens-Johnson syndrome SJS and toxic epidermal necrolysis TEN are severe cutaneous adverse reactions SCARs, carrying an associated mortality from 5–40%. Known risk factors for SJS/TEN include HIV infection, female gender, and certain HLA genotypes. It is unclear how often Stevens-Johnson syndrome or other rashes occurs with chloroquine use. Although there have been several reported cases of both adults and children developing these rashes while using chloroquine, no studies have looked at how often this actually happens. Very rarely, Stevens-Johnson syndrome/toxic epidermal necrolysis can occur. Very rarely, the skin and mucosa can change to a black-blue colour in a process called dyschromia. Hydroxychloroquine can also exacerbate psoriasis. In patients with glucose-6-phosphate deficiency, hemolysis can occur. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil steven johnson syndrome Ocular Manifestations of Stevens-Johnson Syndrome, Stevens-Johnson and Chloroquine Reticulocytes chloroquine treatment p62Plaquenil and tongue swellDoes hydroxychloroquine affect bone graft healing Stevens-Johnson syndrome erythema multiforme is an acute inflammatory polymorphic disease affecting skin and mucous membranes. All ages may be affected, and the incidence is equal in both sexes. This is a severe disease with a 5%–15% mortality rate. Stevens-Johnson Syndrome. Hydroxychloroquine Plaquenil RheumTutor. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Stevens-Johnson syndrome requires hospitalization, often in an intensive care unit or a burn unit. Stopping nonessential medications The first and most important step in treating Stevens-Johnson syndrome is to discontinue any medications that may be causing it. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. So I have this.seems that some people have a rare reaction to the Plaquenil that causes sever inflamationand cell death actaully of the mucus membranes steven-johnson syndrome. Which are in your.