I have been on plaquenil for about 10 weeks now without much success. I have had the sickness to my stomach and not felt like me including exhausted but it's not as bad as I feared. My hair is coming out slightly Not in clumps are anything, just a little here or there. My doctor said if I don't feel better in a few more weeks, we could switch my medicine. Really though in order not to have worse things happen it is what we have to do. I switched back to cymbalta three days ago and have experienced huge relief. High triglycerides and plaquenil Hydroxychloroquine what is a good dose I'm reading various posts online that says the combination of plaquenil and quinacrine work great together, and that quinacrine helps with fatigue more than plaquenil does. Has anyone tried quinacrine or the combination? Does it work well. I really need something more to help. How about with a family care Doctors give trusted answers on uses, effects, side-effects, and cautions Dr. Namey on plaquenil substitute Plaquenil is also known as hydroxychloroquine, so the parent drug Chloroquine can be substituted. But Chloroquine has significantly higher rate of retinal toxicity, so it isn't used much anymore. Also, Plaquenil appears to effectively reduce flares in patients with lupus not. There are two other DMARDs besides Plaquenil but they are associated with more or worse side effects so they are not used as often. Plaquenil seems to be a good baseline drug to start when first. Vitamin B-12 might help with the hair, ask your doctor about that, well wishes to you and I hope the mtx can help you....((((((((((((((((((((((((((((((((((((((((((((((Jeanneac)))))))))))))))))))))))))))))))))))))))))healing hugz and well wishes and keep us posted on how your doing... Had headaches with the plaquenil so went to the sulfar and predisone. (like i did friday) Take care of yourself and big(((HUGS))) on your journey. He said it would be one that they would have to more closely monitor me on with some blood tests. I was thinking it was methotrexate but I do not want my hair to fall out. It might be coincidence but since on the plaquenil, I have noticed a growth spurt of hair especially at the hairline. Plaquenil made me sick, so I can't take it either, but there are other medicine out there,the doctor's will get you on something that'll help, keep hope..wishes to you and try the methotrexate,to see if it can help... I know it is scary but anything to stop the pain and misfunction of not being able to use my hands or move my knees or not have my ankles cave out and fall. I suspected that I had fibromyalgia on top of the inflammation. I am so relieved but hope I don't start having bad side effects from it like I did before with a very dry mouth and gritting my teeth at night. Plaquenil and quinacrine not working anymore for lupus Plaquenil and corona lupus, Plaquenil substitute - Things You Didn’t Know Not diagnosed with rd but on methotrexate and plaquenilHydroxychloroquine sulfate highChloroquine hydrochloride pdfChloroquin function in lysosomeNatural medicine comparable to hydroxychloroquine Re Plaquenil not working anymore Lizzy, I took 400mg 200 twice a day for 16-18 months forget exact duration, then was reduced to 200 mg daily. But right from the start, I also needed NSAID's for pain. Immune & Autoimmune - Lupus Plaquenil not working anymore. Plaquenil Hydroxychloroquine for use in Autoimmune disease. Side.. Hydroxychloroquine DermNet NZ. Lupus and Plaquenil research. While Plaquenil was not created with the explicit purpose of helping people minimize the disease activity of lupus, a number of clinical trials have been conducted to examine the clinical impact of the medication. I'm reading various posts online that says the combination of plaquenil and quinacrine work. lupus in remission. Plaquenil is not. Plaquenil not working anymore. My Rheum asked me to try adding the Quinacrine to the Plaquenil if no help, she was going to start me on Methotrexate. Not everyone reacts the same to all drugs. I can't promise it will work as well for you you're off Plaquenil - so how well it works alone, IDK. This is just my experience with it. It isn't manufactured anymore. I.