Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties. Chloroquine lysosomal inhibitor sigma Fda report of plaquenil Aralene Jul 15, 2014 Autophagy and cancer. A large body of evidence suggests that the relationship between autophagy and cancer is complex.42, 43 On the one hand, autophagy appears to inhibit malignant transformation, reflecting its capability to limit the accumulation of potentially oncogenic entities like depolarized mitochondria which overproduce potentially genotoxic reactive oxygen species, ROS. PANCREATIC CANCER A rare but aggressive cancer. The pancreas is a vital organ that makes insulin and other hormones, which aid in a number of processes important for good health. While it accounts for only 2% of cancers diagnosed in the United States each year, pancreatic cancer is the 3rd most common cause of cancer-related deaths in the country. Blockade of ERK signaling in KRAS-mutant pancreatic cancer increases the dependence on autophagic flux through different mechanisms and provides a rationale for combinatorial targeting with. In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms). Chloroquine and pancreatic cancer Chloroquine plays a cell-dependent role in the response to treatment of., Pancreatic Cancer - Moon Shots Program MD Anderson Cancer. Does hydroxychloroquine help with inflammation Any prior radiotherapy or combined radio-chemotherapy for pancreatic cancer if completed less than 12 months prior to study inclusion. Known hypersensitivity to trial drugs or hypersensitivity to any other component of the trial drugs. Known glucose-6-phosphate dehydrogenase deficiency. Concurrent use. Adjuvant Effect of Chloroquine on Gemcitabine - Full Text.. Combination of ERK and autophagy inhibition as a treatment.. Chloroquine-Mediated Cell Death in Metastatic Pancreatic.. Jun 22, 2018 Chloroquine has been used for many years to treat patients with malaria, lupus, and rheumatoid arthritis, but more recently, hydroxychloroquine has been evaluated as a treatment for pancreatic cancer, with encouraging preliminary results. Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species ROS related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation. Nov 15, 2015 Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. Note based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested.