Additionally, another exception occurred while executing the custom error page for the first exception. Ototoxicity is, quite simply, ear poisoning (oto = ear, toxicity = poisoning), which results from exposure to drugs or chemicals that damage the inner ear or the vestibulo-cochlear nerve (the nerve sending balance and hearing information from the inner ear to the brain). Taking hydroxychloroquine for ra Malaria treatment drugs chloroquine Ototoxicity have been found when these medications are taken orally in high doses by people with chronic kidney disease. Quinine • chloroquine phosphate Aralen •quinacrine hydrochloride Atabrine •quinine sulfate Quinam The ototoxic effects are very similar to those of aspirin. Mucosal Protectant • misoprostol Cytotec Narcotic. Ototoxicity can affect anyone receiving treatment from the medications listed above. However, the likelihood of developing ototoxicity is highly dependant on which drug is being administered, duration of use, and several other underlying factors, such as kidney function and the use of other ototoxic drugs at the same time. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. The parts of the brain that receive hearing and balance information from the inner ear can also be affected by poison, but this is not technically considered ototoxicity and won’t be covered in this information sheet. Because the inner ear is involved in both hearing and balance, ototoxicity can result in disturbances of either or both of these senses. Chloroquine ototoxicity Chloroquine ototoxicity SpringerLink, Ototoxicity HealthEngine Blog Hydroxychloroquine step 1Hydroxychloroquine binding action of mechanism Most important agents to cause irreversible ototoxicity are Aminoglycosides and Cisplatin. FACTORS INFLUENCING OTOTOXOCITY Drug concentration in inner ear Dose, Absorption, Clearance from body, Selectivity to ear Intolerance Renal and hepatic disease Placental transport Chloroquine, Streptomycin can lead to ototoxicity in fetus Genetic. Ototoxicity. Chloroquine - Wikipedia. Chloroquine - an overview ScienceDirect Topics. Ototoxicity is typically associated with bilateral high-frequency sensorineural hearing loss and tinnitus. Hearing loss can be temporary but is usually irreversible with most agents. Generally, antibiotic-induced ototoxicity is bilaterally symmetrical, but it can be asymmetrical. Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. Vestibular ototoxicity or vestibulotoxicity are terms used to describe ototoxicity that affects the balance organs or the vestibular branch of the vestibulo-cochlear nerve. It is important to note that no drug is known to cause Ménière’s disease, benign paroxysmal positional vertigo, or any other vestibular disorder causing fluctuating.