Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil methotrexate rheumatoid arthritis Why chloroquine is given in loading dose Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells but potentially serious eye toxicity can occur. Nausea and vomiting is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months, also take medication Enbrel, and have Pain Hi everyone, I am wondering if anyone has had a problem with fatigue while on Plaquenil. I have been on it for about. 3 months now. At first, I was nauseous for a week or so, which the dr. told me could be a side effect. After the nausea went away it seemed like my pain got worse for a week or so, and then it gradually got better. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil causes nausea Can Plaquenil cause Nausea? - Page 2 - Treato, Will you have Nausea and vomiting with Plaquenil - eHealthMe What is hydroxychloroquinApo hydroxychloroquineHydroxy chloroquine 400 mg I had this exact issue with Plaquenil generic. I switched to brand name and it was great, no issues. It's not the active ingredient that always causes nausea, it can be the particular binding ingredients used by a certain manufacturer in the making of the pills. Plaquenil causing nausea lupus -. Is extreme fatigue a side effect of Plaquenil?. Will you have Nausea with Plaquenil - eHealthMe. By janlorraine December 15, 2015 at am. After every side effect possible, I finally stopped taking 200mgs of Plaquenil after dinner every day. Now four days later I am still so nauseated I can barely function and I am also still getting horrible headaches and cramps. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur. Find information about common, infrequent and rare side effects of Plaquenil Oral.